Drug discovery preclinical workflow

Preclinical Workflow

  1. Target Discovery
  2. Hit Identification
  3. Hit Validation
  4. Lead Identification
    Lead Optimization
    Clinical Lead Selection
  5. Candidate Nomination

Traditional Approach

  • Genetics and biochemistry
    Phenotypic screen
  • High Throughput Screen or Other ScreeningFormats
  • Hit Validation by Co-crystallization and Binding Assays
  • Medicinal Chemistry Optimization
  • Potency, ADME and Tox